Research Case Studies
Case study examples of how we have enabled research across the UK.
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Can we accurately forecast non-elective bed occupancy and admissions in the NHS? A time-series MSARIMA analysis of longitudinal data from an NHS Trust
Hospitals need to be able to predict their capacity for admitting patients when planning elective surgeries. Researchers funded by HDR UK developed a new model for making forecasts that were more...
Relationship between asthma and severe COVID-19: a national cohort study
Previously, there has been conflicting evidence on how an asthma diagnosis affects the risk of severe COVID-19 cases. A new analysis of health records of 38 million people in England found that...
Intensity of COVID-19 in care homes following hospital discharge in the early stages of the UK epidemic
The COVID-19 pandemic led to a high number of deaths in care homes in the UK and other countries. A study across care homes in Wales has found that hospital discharges contributed only a small...
Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure
Metformin is a commonly used diabetes drug that is also thought to benefit people who have heart failure. Researchers studied large-scale health records to understand the impact of diabetes...
A population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in England
Obesity dramatically increases the risk of death from COVID-19 but, the extent of this risk across different body weights and ethnic groups was not clear. Researchers using health and Census...
Patient-centric characterization of multimorbidity trajectories in patients with severe mental illnesses: A temporal bipartite network modeling approach
People with severe mental illness have a lower life expectancy and a higher risk of physical conditions. To improve how these comorbidities can be detected and predicted, researchers have used...
Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals
Diabetes is not only a major health problem in itself, but it also increases the risk of cardiovascular and kidney disease. Researchers have used national healthcare records to identify the...
An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript
The current standard measure of glucose control is not useful for measuring short-term changes and can struggle to work in people with some blood conditions. Researchers supported by HDR UK used a...
Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
A large-scale clinical trial of a monoclonal antibody treatment for COVID-19 showed that it could reduce deaths by 21 per cent in people who had not mounted a natural antibody response of their own.