A biochemist by training, George was initially involved in the field of Computational Biology following a MSc degree by research on correlated mutations analysis on G-Protein coupled receptors which involved modelling class A G-Protein Coupled Receptors (GPCRs) and drug design. He then proceeded to obtain a PhD in the areas of Chemoinformatics/Bioinformatics at Imperial College of London.

Since 2015, Professor Gkoutos holds the chair of Clinical Bioinformatics a joint appointment between the University of Birmingham Medical School and the University Hospitals Birmingham NHS Foundation Trust. He is a Faculty Affiliate Professor of Clinical Bioinformatics, Berkeley Lab, Associate Director of MRC Health Data Research UK, Co-Director of the WCH-Birmingham Research Institute and Alan Turing Fellow.