21st Century Clinical Trials
Principal Investigator: Martin Landray
Our approach combines EHR data for recruitment and long-term follow-up, protocol-specific software engineering to enhance protocol adherence, digital technology to capture physical and cognitive function with smartphones and sensors, and central statistical monitoring (key risk indicators, principal components analysis) to identify poor site performance. This initiative includes three sub-themes:
Pathway to Impact: Success will be demonstrated through application to large trials in diabetes, cardiovascular and kidney disease supported by NIHR, BHF, and industry partners and will be exemplars for the UK Life Sciences Industrial Strategy.
Enhancing Prospective Cohort Studies
Principal Investigator: Gil McVean
Prospective cohort studies (e.g. Million Women Study, China Kadoorie Biobank, UK Biobank) make increasing use of new Big Data approaches including linkage to routine health data, patient-oriented smartphone technology and remote sensors, multi-modal imaging, and high-throughput biochemical and -omic assays. Our work will address the challenge of converting large, multi-dimensional data into meaningful phenotypes. There are four sub-themes:
Pathway to Impact: Algorithms, software and tools will be evaluated in ongoing research cohorts and clinical studies and made available to the wider community via the HDR UK Information Commons.