Ken is Director of the Computational Health Informatics Program at Boston Children’s Hospital and is the Donald A.B. Lindberg Professor of Paediatrics and Biomedical Informatics at Harvard University. He is trained as a paediatrician and paediatric emergency physician.

He is a member of the National Academy of Medicine and as part of its Leadership Consortium, he co-chairs its Digital Health and AI Action Collaborative, , which addresses the artificial intelligence agenda. He has had a sustained influence on the field of biomedical informatics, innovating in bio-surveillance, federated data sharing, patient control of data, and healthcare interoperability. He leads the Genomic Information Commons  across seven children’s hospitals and directs the PrecisionLink Biobank for Health Discovery at Boston Children’s Hospital. Mandl also has been elected to the American Society for Clinical Investigation, Society for Pediatric Research, American College of Medical Informatics and American Pediatric Society.