Jonathan Sterne is Professor of Medical Statistics and Epidemiology in the University of Bristol’s Department of Population Health Sciences, and Deputy Director of the NIHR Bristol Biomedical Research Centre (BRC), within which he leads cross-cutting work on informatics. He has a longstanding interest in using health care data to understand patients’ prognosis and the effects of interventions. Jonathan leads a large-scale collaboration of HIV cohort studies that led to advances in our understanding of prognosis of HIV positive people in the era of effective antiretroviral therapy. He co-led development of tools to assess risk of bias in randomized trials and non-randomized studies that are used in systematic reviews worldwide.