Jonathan Sterne is Professor of Medical Statistics and Epidemiology in the University of Bristol’s Department of Population Health Sciences, and Director of the NIHR Bristol Biomedical Research Centre (BRC). He leads a large team analysing data within the new English whole-population Secure Data Environments (OpenSAFELY and the NHS England SDE). He has a longstanding interest in using health care data to estimate the comparative effectiveness of interventions and understand patients’ prognosis. Jonathan leads a large-scale collaboration of HIV cohort studies that led to advances in our understanding of prognosis of HIV positive people in the era of effective antiretroviral therapy. He co-led development of tools to assess risk of bias in randomized trials and non-randomized studies that are used in systematic reviews worldwide.